miR-146a Is Critical for Endotoxin-induced Tolerance
نویسندگان
چکیده
منابع مشابه
Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate endotoxin/LPS induced miR-146a and 155 in macrophages. However, only miR-146a over expression, b...
متن کاملCoordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages.
Endotoxin tolerance occurs to protect the organism from hyperactivation of innate immune responses, primarily mediated by macrophages. Regulation of endotoxin tolerance occurs at multiple levels of cell responses and requires significant changes in gene expression. In the process of macrophage activation, induced expression of microRNA (miR)-155 and miR-146a contributes to the regulation of the...
متن کاملInterleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands.
Unwarranted overproduction of cytokines, such as interleukin (IL)-1β, can cause moderate to severe pathological complications, and thus elaborate mechanisms are needed to regulate its onset and termination. One such, well-known, mechanism is endotoxin tolerance, generally described as controlling lipopolysaccharide Toll-like receptor 4 (LPS-TLR4) signaling. Similarly, cytokine-induced tolerance...
متن کامل1 Microrna - 146 a Is Critical for Endotoxin - Induced Tolerance . Implication on Innate
MICRORNA-146A IS CRITICAL FOR ENDOTOXIN-INDUCED TOLERANCE. IMPLICATION ON INNATE IMMUNITY Md A. Nahid, Kaleb M. Pauley, Minoru Satoh, and Edward K.L. Chan From Department of Oral Biology, Department of Oral & Maxillofacial Diagnostic Sciences, and Division of Rheumatology and Clinical Immunology, Department of Medicine, and Pathology, Immunology, and Laboratory Medicine, University of Florida, ...
متن کاملmiR-146a is essential for lipopolysaccharide (LPS)-induced cross-tolerance against kidney ischemia/reperfusion injury in mice
MicroRNA-146a is one of most important microRNAs involved in development of endotoxin tolerance via (toll-like receptors) TLRs/ NF-κB pathway. In this study, we sought to identify the mechanistic role of miR-146a in mediating the protective effect of lipopolysaccharide (LPS) pretreatment on kidney ischemia/reperfusion injury. A locked nucleic acid-modified anti-miR-146a given before LPS treatme...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.056317